PATIENT INFORMATION LEAFLET

'ZOLADEX'

The name ot your medicine is 'Zoladext. The active ingredient is goserelin. Each

'Zoladex' injection contains 3.6 mg of goserelin. It also contains lactide-glycolide

copolymer which is an inactive substance.

'Zoladex' is produced in packs of one injection.

Goserelin is one of a group of medicines called LHRH analogues. In men, it reduces

the production of testosterone in the body and, in women, it reduces the

production ot oestrogen in the body.

The product licence holder and manufacturer of 'Zoladex' is

ZENECA Limited

Macclesfield Cheshire United Kingdom.

PLEASE READ THE SECTION OF THIS LEAFLET WHICH APPLIES

TO YOU - EITHER MALE OR FEMALE.

'Zoladex' is used to treat prostate cancer.

'Zoladex' should not be given if you have previously had sn allergic reaction to this type of medicine.

Zoladex' shouid not be given to children.

Have you had any problems passing urine or have you had any problems with your back7 If so, tell your doctor.

If you go into hospital, tell the medical staff that you are receiving 'Zoladex'.

'Zoladex' is yiven as an injection under the skin every 28 days by your doctor or a nurse. It is important that you keep on receiving your treatment, even if you are feeling well, unless your doctor decides that it is time for the treatment to stop.

As with all medicines, undesirable events can sometimes be experienced with 'Zoladex'. These may include hot flushes and a decrease in libido and sometimes breast swelling and tenderness. In some men, there can be bone pain or possibly some problems with passing urine at the beginning of treatment. If this happens, tell your doctor about it. Other possible undesirable events are skin rashes or pain in the joints.

Do 1lot be alarmed by this list of possible events. You may not have any of them.

If you get any other undesirable events or if you think your medicine is causing any problems, tell your doctor or pharmacist.

You may be given a prescription and asked to get your medicine from the pharmacy and keep it until you see the doctor again. Keep it in its original package and don't break the seal. Store it below 25oC and keep it in a safe place where children cannot see it or reach it.

Your medicine should not be used after the expiry date on the carton.

If your medicine is not used, take it back to your pharmacist.

Date of preparation of leaflet: Mav 1995

This leaflet does not contain the complete infommation on Zoladex'. If you have any questlons, or a re not su re about anything, ask you r doctor or phammadst.

The infommation applies only to Zoladex'.

'Zoladex' can be used to treat breast cancer, endometrlosis or to make the lining of the uterus thinner before having an operation.

'Zoladex' should not be given if you are pregnant trying to become pregnant or if you are breast

'Zoladex' should not be given to children.

If you are receiving 'Zoladex' for endometriosis, you should only receive treatment for a maximum of six months.

Medicines of this type can cause a small loss of calcium from the bones. Some recovery of this loss can occur when treatment is stopped.

Whilst receiving Zoladex', barrier methods of contraception such as the condom or diaphragm (cap) should be used. Oral contraceptives (the aPill~) should not be taken when receiving 'Zoladex'.

If you go into hospital, tell the medical staffthat you are receiving Zoladex'.

'Zoladex' is given as an injection under the skin every 28 days by your doctor or a nurse. It is important that you keep on receiving your treatment, even if you are feeling well, unless your doctor decides that it is time for the treatment to stop.

As with all medicines, undesirable events can sometimes be experienced with 'Zoladex'. These may mclude hot flushes and sweating, decrease in libido, headaches, mood changes including depression, vaginal dryness and change in breast size. Other possible undesirable events are skin rashes or pain in the joints.

Occasiona!)y some women enter the menopause eariy, so when Zoladex' treatment is stopped menstruabon wi(l not start again.

At the beginning of treatment, a worsening of symptoms of your breast cancer such as an mcrease In pam and/or an morease in the size of the affected tissue may occur. In addition if you experience excessive nausea, vomiting or thirst, you should tell your doctor. This may indicate possible changes in the amount of calcium in your blood and your doctor may have to do certain blood tests.

Do not be alarmed by this list of possible events. You may not have any of them.

If you get any other undesirable events or if you think your medicine is causing any problems, tell your doctor or pharmacist.

You may be given a prescript,on and asked to get your medicine from the pharmacy and keep it until you see the doctor again. Keep it in its original package and don't break the seal. Store it below 25°C and keep It in a safe piace where children cannot see rt or reach rt.

Your medicine should not be used after the expiry date on the carton.

If your medicine is not used, take h back to your pharmacist.

Date of preparation of leafle'c May 1995

This leaflet does not contain the complete information on 'Zoladex'. If you have any questions, or are not sure about anything, ask your doctor or phammacist.

The information applies only to Zoladex'.

'Zoladex' is a trademark.