'TENORET'

Please read this leaflet carefully before you take your

medicine. This leaflet only gives a summary of the

information available on your medicine.

If you have any questions or are not sure about

anything, ask your doctor or pharmacist.

The name of your medicine is 'Tenoret' 50.

The active ingredients are atenolol and chlorthalidone.

'Tenoret' 50 is produced as tablets which contain 50 mg

of atenolol and 12.5 mg of chlorthalidone.

Your medicine also contains the following inactive ingredients:

gelatin, iron oxide, macrogol, magnesium carbonate,

magnesium stearate, methylhydroxypropylcellulose, sodium

lauryl sulphate and maize starch.

'Tenoret' 50 tablets are produced in packs of 28, 30, 500 and

504 tablets. Some of the pack sizes quoted are not available.

Atenolol is one of a group of drugs called beta blockers. It has

effects on the heart and circulation. Chlorthalidone is one of

a group of drugs called diuretics. It increases the amount

of urine produced by the kidneys.

The product licence holder and manufacturer of 'Tenoret' 50

is:

ZENECA Limited

Macclesfield Cheshire United Kingdom

'Tenoret' 50 is used to treat hypertension

(high blood pressure).

Do not take Tenoret 50 i' YoU have previoushy had an allergic reeceon to n or to atenolol or chlonhalidone

Tenoret 50 should not be taken by people whh heanfailure which is not under contol or with cenain of her condeions such as hean block, very slow or very irregular hean beats, very low blood pressure or very poor circulaton. h should also not be taken bY people whn have phaeochromocytoma which is not being reatedorbYpeoplewhohavemetabolicacidosis.Yourdoctorwillknowaboutthesecondib'ons

Do not take Aenoret 50 it vou aro pregnant or d vou are breast feeding a baby

DovouhaveapancularrypeolchestpaincalledPnnzmetal'sangina?ltsoStellyourdoctor Do vou have asthma or do vou get allergic reactons to such things as insect sangs7 If so, tell y vur doctor Do vou have d abetes? Tenolef 50 maV change your normal response to low blood sugar, which usually involves an increase ill hean rate Dp you have thyrutoxi osis7 Tenoret SO may hide fSe symptoms of fhyrotot icosis.

DovouhavekidlleYproblems71tsoStalktovourdoctorbecausevoumayneedtohavesomecheckupsduringeourtteatment

Are vou taking anV uther medicines7 1t so, tell your doctor. Tenoref 50 can intef ere wrth fhe achon of some odher drugs and some drugs can have an eHect on Tenoref 50 The drugs which can cause some problems when taken together wnh Tenoref 50 are verapamil, diXdarem, ndedipine (which are used to treat hypenension or angina), disopyramide llor irregular hean beatsi, digo on if or hean failurel, adrenaline {a hean sdmulant), ibupr :fen and indomethacin ltor pain and Ililammation) and lith vIm RPr depressionl

AIP yntl takinq a drilg callcd clonid~ne If or hypenension or migraine)7 11 you ale taking clonidine and Tenolet 50 together, vou must not stop taking clorlidine unless vollr doctos tlells yo l lo dg s 1e it becomes necessary tor vou to stop taking the elonidine, your doctor wiil give VoU careful instructions on how to do it

It you go into hospital tu have an operaton, tell ff e anaestheost ol fhe medicaj staff fhat VoU ale taking Tenoret so

Vou med ine is un ikeiy to a dect your abi dY to dn te or to operate machinery. Howeyer, some people may occasionally feel di tzy or uled when taking Tenoret

Tenoref 50 tablets should be swallowed FoDow yeur doctor s inst uctons about when and how tst Uke your medicine Also read fhe label Your phammacist can also help if you are not sure

Your doctor will have decided what dose vou should hake each day depending on ysur cond don. The usual daihy dose for an 2duh is one tablet

|t vou forget to take voul medicine. take voul dose when you remember and fhen take your netet dose at dhe usual ome Don t take two doses at fhe same tme If you are worried. ask your doctol ol phammacist tor ad ice

If you accidentally take an overdose of your medicine, eAher ca9 your doctpr straight away, or go to your nearest hospital casuaRy depanment Aiways take any remaininitablets,dhe containerandShelabelwhhyoursothatthe medicine can bendentthed.

nn not sioo takino vour medicine wnhout taSbno tp vour docpor hrst In some cases. n may be necessary to stop tabng the medicine gradualhy

As wsth alj medicines, undosirabie events can sometmes be etepenenced wnh Tenoref S0. Occasionalhy, a few people can suYer hrom cold hands and feeg tredness, slow hean beat headache. dry mourh, nausea, diarrhoea, disturbed sleep, fhinning of dhe hair, mood changes, conhusion. psychoses or hallucinanons. bruising mole easily or purplish marks on fhe skin, nngl~ng of fhe hands, dry eyes, disturbances of vision, skin rashes, worsening of psoriasis or dittiness panicularly whell standing up Dther possible events which may occur in suscepuble people are numboess and spasm in fhe hngers IRaymaud s phenomenon), hean block lwhich can cause dittiness or fainong), wersening of hean failure in people with hean failure, worsening of breathing dihEcuRdes in people whh asUbma or breathing problems or worsening of fbe circuladon in people wnh poor circulaecn Dther possible events are a reducton in fhe amoUDt of potassium in the blood, an increase in the amount of unc acid in the bl:od or a reduction in dhe number of whne blood cells Yourdoctor mEytake blood samples every so ohen to check on these levels

Do not be alarm d by th s ist of possibie events You ntay not have any f ffem.

Checkthe ettpirydate on the canon and don tusethe medicine aherthatdate.

Keep V° medicine in a sale place where children cannot see it or reach t Your medicine could harm fhem

Keep your modicine below 25°C and awaV from strong light and dampness

H Vour doctor de cides to stop treatment return any leh-over tablets to your phanmacist Only keep fhem if fhe doctor tells Y°U to

Date ot niepalation ol leadet: June 1595

This leallet does not contain fhe complete infommadon on Tenoref SO If yeu have any quesdons, or are not sure about anything, ask your doctor or pharmacist

Remember: This medicine is for you Dnly a doctor can prescribe hfor you Never give n so someone else It mayharm dhem even if their symptoms are the same as VoIIrS

The Inlorneation applies onN to Teliplet 50

'Tenoret' 50 is a trademark.

5/lE/UK/1014708