This leaflet provides important information on your medicine. Please read it carefully before you start taking LEDERFEN capsules. Ii you have any questions or are not sure about anything, ask your doctor or pharmacist (chemist). Keep this leaflet while you are taking LEDERFEN capsules, you may want to read it again.

LEDERFEN capsules contain 300mg fenbufen per capsule. They belong to a group of medicines called "non-steroidal anti-inflammatory agents" which are usually taken to relieve pain, stiffness and inflammation.

Other ingredients in these tablets are sucrose, pre-gelatinised starch. magnesium stearate, sodium lauryl sulphate, titanium dioxide (E171) and F D and C Blue No.2 (E132).

T he total sodium content of each capsule is 0.24mg.

The holder of these licenses and the Manufacturer of the capsules is:-

Cyanamid of Great Britain Ltd. Fareham Road, Gosport, Hants, PO13 0AS, England LEDERFEN Capsules are supplied in a blister pack of 84 capsules.

LEDERFEN capsules are used to relieve some symptoms caused by arthritis or rheumatism such as inflammation, swelling, stiffness and joint pain. This medicine will not cure arthritis but will help you as long as you continue to take it. They may also be used to relieve other painful conditions of the joints or muscles.

• you are pregnant, or trying to become pregnant or breast feeding.

• you have ever had a bad reaction, such as itching or breathing problems (wheezing or asthma) or stomach pains. after taking aspirin, ibuprofen or other medicines used to treat painful conditions affecting the joints and muscles.

• you have or have ever had a stomach ulcer.

• you have liver, heart or kidney problems.

• you are taking warfarin (to prevent blood clots), certain antibiotics called quinolones, or lithium. Also if you are taking any drugs to lower your blood sugar (hypoglycaemics or sulphonylureas), aspirin or aspirin-like drugs or methotrexate.

• you are taking any other medicines or capsules including those you have bought without a prescription.

This medicine should not be given to children under the age of 14.

When you take LEDERFEN capsules you may have blurred vision. Do not drive or operate machinery if this happens to you.

The dosage for LEDERFEN varies from person to person depending on your individual condition. You will probably be asked to take one capsule in the morning and two at night.

Your doctor may suggest a different dose depending on your condition. Always take the number of capsules your doctor has told you to take. This information will also be on the pharmacist's label.

Your pharmacist (chemist) may also help if you are not sure of how or when to take your capsules.

LEDERFEN capsules should be swallowed whole with a drink of water. The capsule should not be chewed or sucked.

If you accidentally take more than 4 capsules in one day (an overdose), contact your doctor or local casualty department immediately. Always take the labelled pack with you, even if there are no capsules left.

Take it as soon as you remember, and continue to take your medicine as usual providing you do not take more than 3 capsules in one day.

Like all medicines, LEDERFEN capsules may cause unwanted effects in some people. If you get a rash, wheezing or shortness of breath, STOP TAKING LEDERFEN capsules and see your doctor immediately Some other unwanted effects may sometimes be seen when you are taking LEDERFEN capsules, these are described below. If these or any other unusual symptoms become troublesome, please contact your doctor or pharmacist (chemist).

The following symptoms are occasionally seen in patients taking these capsules: vomiting, sometimes of blood; stomach pain; heartburn; diarrhoea; black stools; constipation; irritation, dryness or soreness of the mouth; loss of appetite; swelling of the face, feet or lower legs; dizziness; depression; trouble in sleeping; numbness in your hands or feet; severe headache; tiredness or generally feeling unwell; disturbance in vision, ringing or buzzing in your ears or your skin may become more sensitive to sunlight.

The following may be seen rarely:

unexplained sore throats, chills or fever; unexplained bleeding from the gums or nose; unusual bleeding or bruising, or jaundice (yellowing of skin), bloody or cloudy urine, a large increase or a sudden decrease in the amount of urine, increased sweating or flushing.

Check with your doctor before you take any other medicines.

If you have to have a blood test tell your doctor that you are taking LEDERFEN capsules as they may affect the outcome of the test.

If you will be taking this medicine for more than 3 months, ask your doctor if you need to have regular check-ups.

If you still feel unwell at the end of the prescribed course of medicine, tell your doctor.

Keep your capsules in a dry place at room temperature (below 25°C). Keep all medicines in a safe place, away from children.

If your doctor decides to stop treatment, return any LEDERFEN capsules you have left to your pharmacist (chemist). Medicines should not be put down the sink, toilet or in the bin.

Do not use after the expiry date. This date is printed on your pack.

Date of Preparation or last Review: December 1994

This leaflet does not contain the complete information about your medicine. If you have any questions or are not sure of anything, ask your doctor or pharmacist (chemist) who can give you more information. The information in this leaflet applies only to LEDERFEN capsules.

The product licence number is: PL 0095/0043

* Registered Trademark

Distributed by: Lederle Laboratories, Cyanamid House, Fareham Road, Gosport, Hampshire PO13 0AS.

© Copyright of Cyanamid of Great Britain Ltd. - 1994

30M 9/95 Q51425