Your medicine is called Maloprim Tablets (containing pyrimethamine and dapsone). It belongs to a group of medicines called antimalarials. It is used as a form of protection against malaria in areas where the malaria parasite is sensitive to pyrimethamine/dapsone.

1. Make sure it is alright for you to take Maloprim {see the back of this leaflet.
1. Take your tablets as directed by your doctor, and read the container label carefully. It is important to complete the prescribed course, even on return from a malarious area.
1. Maloprim may sometimes cause unwanted effects. You can find these listed on the back of this leaflet.†
1. Keep your tablets out of reach of children.



1. Remember if you are left with any tablets which you no longer require or which have passed their "use by" date, return them to your pharmacist for disposal.

Ask these questions before taking Maloprim Tablets:

• Are you currently taking or likely to be taking any other medicines whilst you are taking Maloprim?
• Have you previously experienced an allergic reaction to Maloprim, sulphonamides, pyrimethamine or dapsone?
• Are you pregnant, trying to become pregnant, or breast feeding?
• Do you suffer from any liver, kidney or blood disease (eg. anaemia)?
• If these tablets are for your child, is your child under 5 years old?

If the answer is YES to any of these questions, and if you have not already discussed them with your doctor or

pharmacist, tell them before you take this medicine.

Adults and children over 10 years: 1 tablet regularly once weekly.

Children 5 to 10 years: Half a tablet regularly once weekly.

You should take your first tablet during the week before going to a malarious area, and you must continue your

weekly tablet throughout your visit and for a further 4 weeks after your return.

• Do NOT exceed the stated dose.
• Swallow the tablet with some water.
• If you forget to take a dose, take it as soon as you remember. Then go on as before. Extra precautions to protect yourself against malaria should be taken - see below.
• REMEMBER THAT NO ANTIMALARIAL AGENT GIVES COMPLETE PROTECTION. FURTHER PRECAUTIONARY MEASURES, SUCH AS COVERING EXPOSED AREAS OF THE BODY, APPLICATION OF INSECT REPELLANTS AND THE USE OF MOSQUITO NETS IS ADVISED.
• In the event of an accidental overdose, or if someone else takes your medicine by mistake, contact your doctor immediately.
• ADDITIONAL INFORMATION: It is essential to take medical advice on which antimalarial prophylactic medicine to take. For some countries it may NOT be suitable to take Maloprim.

This medicine is normally well tolerated but may occasionally cause side-effects in some people.

• An unexpected skin reaction, eg. a rash or irritation.
• If you start feeling more tired than usual, become short of breath, or if you get an infection.
• If you develop a high temperature, chills or muscle pains.
• If you become unwell (particularly if you have been taking the medicine for a long time} and you are unable to think of another reason for your feeling unwell.

The Product Licence for Maloprim Tablets is held by The Wellcome Foundation Limited, London, NW1 2BP.

The Product Authorisation for Maloprim Tablets is held in Ireland by Wellcome Ireland Limited, Dublin.

This leaflet is produced in accordance with guidance issued by the Association of the British Pharmaceutical

Industry. The information in it applies only to Maloprim Tablets.

PL 315117 PA 17/84/1

*Trade Mark Made in England

Supplied in the Rep. of Ireland by Wellcome Ireland Ltd Dublin

0/5505 93.03