• You should take the number of tablets prescribed by your doctor. Unless otherwise specified, the usual dose is one tablet twice daily. Your doctor may change the dose according to your response to the treatment.
• You should swallow the tablet(s) whole with some liquid after food. Do not bite, chew or break up the tablet(s).
• You should not take the next dose less than 4 hours after the first dose.

High blood pressure and angina pectoris require long term treatment. Your doctor will monitor your progress and determine the duration of your treatment. If you wish to stop Adipine™ MR 10 temporarily or permanently, your should consult your doctor.

Discontinuation of Adipine™ MR 10 should be gradual, especially if you have been taking high doses.

If you miss a dose and it is more than 4 hours before the next dose, then take your usual treatment. If it is less than 4 hours, then you should wait till your next usual dosing time before taking the medication. You should never take a double dose to make up for the missed dose.

At the start of treatment, worsening of angina pectoris may occur. Patients may experience headache, flushing or reddening of the skin associated with a feeling of warmth.

There have been reports of palpitations, fatigue, dizziness, swollen ankles due to fluid retention, tingling sensation in the arms or legs, muscle pain, finger tremors and minor transient visual disturbances. Rarely there have been reports of diarrhoea, nausea and a feeling of fullness.

Allergic skin reactions have been reported e.g. itching, hives and rashes, and rarely inflammation and peeling of the skin.

Rare reports have been made of abnormalities affecting the blood cells (reduced red and white cells and platelet counts) and of spontaneous bleeding Swelling of the breasts have also been reported, especially in elderly men, and impairment of liver function and swelling of the gums have also known to occur; all of these have resolved on stopping treatment

Patients who are on kidney dialysis and have a very high blood pressure and a low blood volume may have a marked drop in their blood pressure. In those who have kidney impairment, their kidney function may deteriorate transiently.

Should you experience any effects not described above, please let your doctor know immediately.

In case of an overdose, medical advice should be sought immediately.

The tablets should be kept in the original container in a cool, dry place below 25°C.

The expiry date of the medicine is printed on the package. Do not use this product after this expiry date.

Date of preparation or last revision: October 1995

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