Please read this leaflet carefully before your treatment is started. This leaflet provides a summary of the information available on your medicine. If you have any questions or are not sure about anything, ask your doctor.

The name of your medicine is Ukidan. It is available as a white powder in three different strengths containing 5000, 25000 or 100000 IU of the active ingredient which is called urokinase. It will be made up (dissolved) in water or saline before it is given to you. All strengths are available in single vials.

In addition to Urokinase, Ukidan also contains Mannitol, Disodium Edetate and Disodium Hydrogen Phosphate.

Serono Laboratories (UK) Ltd

99 Bridge Road East

Welwyn Garden City

Herts AL7 1BG

Industria Farmaceutica Serono S.p.A

Via Casilina, 125

00176 Rome

Italy

Your doctor has prescribed this medicine for you because you have a condition which is causing unwanted blood clots to form. Ukidan contains Urokinase, a substance which occurs naturally in the body. It is used to dissolve blood clots. There are several conditions that the medicine Is used for, which are described briefly below:

1. To treat thrombosis (blood clot) in a vein or artery
2. To treat hyphaema (bleeding into the chamber of the eye)
3. To unblock the tubes which are used to administer drugs or dialysis if they become blocked by a clot.

Your doctor can explain your treatment to you.

Usually it is alright for you to be given Ukidan if your doctor has prescribed it. However, if you think any of the following situations apply to you then speak to your doctor.

• You are pregnant or think you could be pregnant.

• You have had a baby in the last few days.

• You have had any problems with your liver or kidneys.

• You have very high blood pressure.

• You have a peptic ulcer.

• You have had to be resuscitated in hospital and have therefore had treatment which involved the use of tubes or needles (injections). Your doctor will be able to discuss this with you.

The medicine will be given to you in hospital. As Ukidan is used to treat several different conditions it can be given in different ways. However it is usually given by injection or by infusion through tubes into a vein. The dosage varies depending on what condition you are being treated for and on your weight. The treatment is usually short lasting only a few hours although some conditions involve a series of injections over 3 days. Your doctor or nurse will be able to explain how Ukidan is being given to you.

Any medicine can cause side-effects. However most people who are given Ukidan do not have any problems.

If however you are receiving Ukidan to clear a dialysis shunt tube you may get a warm feeling some pain or a dull ache in the leg or arm itself. The pain should not East long.

It is also possible that you may suffer from bleeding. This may only be slight but if you notice any bleeding then call a doctor or nurse. You may have a temperature for a short time. Occasionally some blood may appear in your urine.

If you notice these or any other unwanted effects not mentioned above then please tell your doctor or nurse.

Ukidan should be stored in a fairly cool place. Once the powder has been made up it can be kept for 24 hours in a cool place (below 25°C). It is important not to use the medicine after the date shown on the box.

Date of preparation: January 1995

This is only a summary of the information that is available on Ukidan. If you have any questions after reading this leaflet please ask your doctor who will have additional information.

Code:N0220200 UK