PLEASE READ ALL OF THIS LEAFLET CAREFULLY IF YOU HAVE BEEN GIVEN OR WILL BE GIVEN COGENTIN INJECTION.

Keep this leaflet. You may want to read it again.

Active ingredients: The active ingredient in Cogentin Injection is benztropine mesylate.

Cogentin Injection contains 2 mg benztropine mesylate BP, as a colourless solution.

Other ingredients: The other ingredients in Cogentin

Injection are sodium chloride EP and water for injections EP

Cogentin Injection is supplied in 2 ml ampoules.

The active ingredient in your injection is benztropine mesylate. Benztropine mesylate is a medicine which has strong 'anticholinergic' effects. This means that it works by decreasing the amount of a chemical in the brain called 'acetylcholine’. This chemical is naturally occurring but, if levels of this chemical in the body are too high, it causes movement difficulties.

Cogentin Injections are made by Merck Manufacturing Division, Merck Sharp & Dohme-Chibret, Bvd Etienne Clementel, Clermont-Ferrand, France, for Merck Sharp & Dohme Limited, Hoddesdon, Hertfordshire, UK, who hold the Product Licence in the UK and the Product Authorisation in Ireland.

Your doctor has prescribed Cogentin for you because you have Parkinson's disease, or symptoms which are seen with this condition, caused by some other drugs you may have taken such as phenothiazines or reserpine. These symptoms may include tremor and difficulty with moving. Your injection will help restore the balance of acetylcholine in your body and help to control your movement difficulties.

Cogentin Injection is given to patients when it is inappropriate for them to take the medicine by mouth.

Yes; you should not get the injection if you have had a bad reaction to this or similar medicines, or to any of the ingredients in the past.

In addition, Cogentin should not be given to children under the age of 3 and should be used with caution in older children.

If you think any of these apply to you, wait until you have talked to your doctor before getting the injection and follow his advice.

You should check with your doctor before receiving Cogentin if:

• you are or think your may be pregnant
• you are planning to become pregnant
• you are breast-feeding
• you are a man who knows he has a prostate problem
• you have heart problems
• you are easily confused or easily excited
• you have glaucoma.

Can you take Cogentin with other medicines?

Some other medicines do interfere with Cogentin. These are: anticholinergic medicines, other anti-Parkinson treatments, medicines used to treat depression, and phenothiazines. Your doctor will know which ones these are. If you are taking any of these medicines you should talk to your doctor about them.

It is important that you tell your doctor about all the medicines you are taking, including those obtained without a doctor's prescription.

Cogentin may cause you to fail to sweat properly in hot weather, especially if taken with other atropine-like drugs when you have been chronically ill, have a central nervous system disease, suffer from alcoholism, or work in a hot environment. During hot weather, or if you have an existing disturbance with sweating, you should use Cogentin cautiously. Should your sweating decrease while you are taking Cogentin, tell your doctor immediately, as your body temperature could become very high, and your dosage may need to be decreased.

You will have been given or are about to be given Cogentin Injection by a healthcare professional. The number of injections you require will depend upon your condition. Your Cogentin Injection will be given to you either into your muscle or into your vein by your healthcare professional. Your doctor or pharmacist will advise you of when you need your next injection. Cogentin Injection must not be taken by mouth.

It is probable that the times at which you are to have your injections will be set by your healthcare professional. However, if you think you may have missed a dose, or have been given too much medicine, you should notify your doctor as soon as possible.

What unwanted effects could your medicine have?

Like all medicines, Cogentin may occasionally cause side effects in some patients. These side effects may include sensitivity to heat, constipation, nausea, sickness, dry mouth, racing of the heart, confusion, visual hallucinations, impaired memory, blurred vision, changes in urine flow, pain when passing urine, skin rashes and fever.

Some patients may experience worsening of the symptoms they already have, including nervousness, depression, numbness of the fingers and listlessness.

Should you experience any of these symptoms, you should consult your doctor.

Keep your medicine out of the reach of children. It should be stored in a cool place, out of direct sunlight.

Cogentin Injection should not be allowed to freeze.

Cogentin Injection should not be used after the expiry date which is clearly marked on the pack.

REMEMBER, this medicine is for you. Do not share it with anyone else. It may not suit them.

Date of Issue: 1994.

This leaflet gives you some important patient information about Cogentin. If you have questions after you have read it, ask your doctor or pharmacist, who will give you further information.