Suprefact contains buserelin (as buserelin acetate, 100 micrograms in each spray). It also contains citric acid, sodium chloride, sodium citrate, onium chloride and water. It is a nasal spray; one bottle contains 84 spray doses ( 1 week's treatment).

Buserelin is one of a class of medicines called LHRH analogues. It works by decreasing the production of sex hormones.

The product licence for Suprefact is held by Hoechst UK Ltd, Hoechst House, Salisbury Road, Hounslow, Middlesex, TW4 6JH.

Suprefact is made by Hoechst AG, D-65926 Frankfurt am Main, Germany.

Suprefact is used to treat cancer of the prostate gland by reducing levels of the sex hormone testosterone.

Tell your doctor if you have diabetes or high blood pressure of if you have ever suffered from depression.

Tell your doctor if you are taking any other medicines.

Tell your doctor of any problems you have had with this or other medicines in the past.

Follow your doctor's advice about when and how to use your medicine and look at the label and leaflet. Your pharmacist may also help if you are not sure.

The usual dose needed to reduce hormone production is two sprays (one into each nostril) six times a day. This is best taken as one spray into each nostril before and after breakfast, one spray into each nostril before and after the midday meal and one spray into each nostril before and after the evening meal.

To keep hormone levels lowered, it is very important to take all your Suprefact doses regularly every day.

You can continue to use Suprefact if you have a cold. Blow your nose well before using the spray. If you are using a nasal decongestant do not use the decongestant for at least 30 minutes after you have used Suprefact.

If you miss a dose of Suprefact, take another as soon as you remember unless it is nearly time for your next dose. Never double-up on the next dose to make up for the one you missed.

If you take too much Suprefact tell your doctor.

Any medicine can have side-effects.

You may notice symptoms such as hot flushes, sweating or enlargement of the breasts or you may have a decreased interest in sex. These symptoms may not appear until several weeks after starting treatment. If they are severe tell your doctor.

At the beginning of the treatment the amount of sex hormones may be increased and you may notice a

temporary worsening in symptoms. Usually you will be given another medicine to prevent this.

Some people find that the nasal spray irritates the nose and may even cause nosebleeds or make you feel hoarse. If you have any problems tell your doctor. Most people do not have any other side effects to Suprefact. However, if you notice any of the following symptoms tell your doctor and ask if you should continue using the nasal spray:

• Headaches, palpitations, feeling tired, nervous, drowsy, depressed, anxious or emotional, have disturbed sleep or lapses in memory or concentration.
• Have a problem with hearing or seeing or have a feeling of pressure behind the eyes.
• Stomach upsets (e.g. feel or be sick, constipation, diarrhoea), feel thirsty or notice any changes in weight or appetite.
• Back or limb pains, or joint discomfort.
• Shortness of breath, reddening of the skin, itchy rash or asthma.
• Increase or decrease in scalp or body hair.

If you feel unwell after using the spray, or notice anything unusual or unexpected, tell your doctor.

Keep your nasal spray in a cool dry place. Do not freeze it. Do not use it past the expiry date on the bottle.

One bottle has enough solution to last one week. You should stop using a bottle at the end of one week and start a new bottle.

Keep the spray in a safe place where children cannot reach it. Your medicine could harm them.

If your doctor decides to stop the treatment, return any leftover spray to your pharmacist so that it can be disposed of safely. Only keep it if your doctor tells you to .

Remember this medicine is for you. Only a doctor can prescribe it for you. Never give it to other people. It may harm them, even if they have the same symptoms as you.

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist, who have access to additional information.

This leaflet only applies to Suprefact Nasal Spray. Last revision June 1995.

1. Remove screw cap from bottle.
1. Remove metered-dose nebulizer from transparent plastic container and take off both protective caps.
1. Screw nebulizer on to bottle.
1. Before first application only, pump 5 8 times, holding bottle vertical, until the solution has filled the system and a uniform spray is emitted. The preliminary pumping is for the purpose of filling the system and testing the spray. It must not be repeated after the first use, in order to avoid wasting the contents.
1. Keeping bottle vertical and bending head over it slightly, spray solution into nose. If necessary, the nose should be cleaned before applying the solution.
1. After use leave nebulizer on bottle. After replacing protective cap, spray bottle is best stored in its transparent container in an upright position.