Author: Unknown

Suprecur Nasal Spray

Please read this carefully before you start to take your medicine. This leaflet only provides a summary of the information available on your medicine. If you have any questions, or are not sure about anything, ask your doctor or pharmacist.

What is Suprecur?
Suprecur contains buserelin (as buserelin acetate, 150 micrograms in each spray). It also contains citric acid sodium chloride, sodium citrate benzalkonium chloride and water. It is a nasal spray; one bottle contains 84 spray doses (2 weeks treatment for endometriosis) .
Buserelin is one of a class of medicines called LHRH analogues. It works by decreasing the production of sex hormones.
The product licence for Suprecur is held by Hoechst UK Ltd, Hoechst House, Salisbury Road, Hounslow Middlesex, TW4 6JH.
Suprecur is made by Hoechst AG, D-65926 Frankfurt am Main, Germany.

Why use Suprecur
Suprecur is used to treat endometriosis and also as part of a treatment for infertility.

Before taking your medicine
Tell your doctor if you are pregnant or breast feeding.
Tell your doctor if you are diabetic, have high blood pressure or have ever suffered from depression.
Tell your doctor if you are taking any other medicines.
If you are being treated for endometriosis, tell your doctor if you are using oral contraceptives (the pill). You should change to another (barrier) form of contraceptive during treatment with Suprecur. Tell your doctor of any problems you have had with this or other medicines in the past.
If you feel drowsy after taking this medicine, do not drive or operate machinery.

How should I use Suprecur?
Follow your doctor's advice about when and how to use your medicine and look at the label and leaflet. Your pharmacist may also help if you are not sure. You should start treatment on the first or second day of your period.
The usual dose for the treatment of endometriosis is two sprays (one into each nostril) three times a day. This is best taken in the morning, at mid-day and in the evening. For use as part of infertility the usual dose is one spray (in one nostril only) four times a day. Some clinics use higher doses.
It is very important to use Suprecur at regular intervals throughout the waking hours.
You can continue to use Suprecur if you have a cold. Blow your nose well before using the spray. If you are using a nasal decongestant do not use the decongestant for at least 30 minutes after you have used Suprecur.
If you miss a dose of Suprecur, take another as soon as you remember unless it is nearly time for your next dose. Never double-up on the next dose to make up for the one you missed.
If you take too much Suprecur tell your doctor as soon as possible.

What undesirable effects may Suprecur cause?
Any medicine can have side-effects.

You will probably have a period during the first few weeks of treatment. After this your periods will probably stop, although some people may bleed again.
You may notice symptoms such as hot flushes,
sweating or you may have a dry vagina, decreased interest in sex or find intercourse painful.
Cysts (swellings) can sometimes occur in the ovaries with buserelin but do not interfere with treatment.
During long term treatment the amount of calcium in bone may decrease. Most of the calcium is regained when treatment is stopped.
Some people find that the nasal spray irritates the nose and may even cause nosebleeds or make you feel hoarse. If you have any problems tell your doctor. Most people do not have any other side effects to Suprecur. However, if you notice any of the following, tell your doctor and ask if you should continue using the nasal spray:
–	headaches, palpitations, feeling tired, nervous, drowsy, depressed, anxious or emotional: have disturbed sleep or lapses in memory or concentration.
–	have a problem with hearing or seeing or have a feeling of pressure behind the eyes.
–	stomach pain or upsets (e.g. feel or be sick, constipation, diarrhoea), feel thirsty or notice any changes in weight or appetite.
–	breast tenderness, or changes in the size of the breast, splitting nails, spots, dry skin or vaginal discharge.
–	back or limb pains, or joint discomfort.
–	shortness of breath, reddening of the skin, itchy rash or asthma.
–	increase or decrease in scalp or body hair.
If you feel unwell after using the spray, or notice anything unusual or unexpected, tell your doctor.

How should I store Suprecur?
Store your nasal spray below 256C. Do not freeze it. Do not use it past the expiry date on the bottle.
One bottle has enough solution to last two weeks if you are being treated for endometriosis at the usual dose. You should stop using a bottle at the end of two weeks and start a new bottle. If you are using Suprecur as part of an infertility treatment the one bottle can be used for up to five weeks after first opening.
Keep the spray in a safe place where children cannot reach it. Your medicine could harm them.
If your doctor decides to stop the treatment, return any leftover spray to your pharmacist so that it can be disposed of safely. Only keep it if your doctor tells you to.
Remember this medicine is for you. Only a doctor can prescribe it for you. Never give it to other people. It may harm them, even if they have the same symptoms as you.
This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor or pharmacist, who have access to additional information.

This leaflet only applies to Suprecur Nasal Spray. Last revision February 1996.

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How to use the spray bottle
1.	Remove screw cap from bottle.
2.	Remove metered-dose nebulizer from transparent plastic container and take off both protective caps .
3.	Screw nebulizer on to bottle.
4.	Before first application only, pump 5-8 times holding bottle vertical, until the solution has filled the system and a uniform spray is emitted. The prelimi-

nary pumping is for the purpose of filling the system and testing the spray. It must not be repeated after the first use, in order to avoid wasting the contents.
5.	Keeping bottle vertical and bending head over it slightly, spray solution into nose. If necessary, the nose should be cleaned before applying the solution.
6.	After use leave nebulizer on bottle. After replacing protective cap, spray bottle is best stored in its transparent container in an upright position.