1. Make sure it is safe for you to take Ismelin (see the back of this leaflet).
2. Take your tablets as instructed by your doctor and read the label on your tablets.
3. These tablets may cause unwanted effects in some people. You can find information about them on the back of this leaflet.
4. Do not stop taking your tablets suddenly. Ask your doctor first.
5. Keep your tablets in a dry place out of reach of children.
6. Ismelin tablets are not suitable for use in children.
7. Remember to return any unused medicine to your pharmacist.

Isemlin is an anti-hypertensive medicine used to reduce high blood pressure.

• Ismelin tablets come in two sizes. White tablets marked Ismelin 10 containing 10mg of guanethidine monosulphate and pale red tablets marked Ismelin 25 containing 25mg of guanethidine monosulphate.
• These tablets aiso contain lactose and gluten (wheat starch).

• Are you allergic to guanethidine?
• Do you suffer from any serious heart, kidney or glandular disorder which your doctor does not know about?
• Are you taking or have you recently taken any medicines to treat depression particularly monoamine oxidase inhibitors [MAOls]?

If the answer to any of these questions is

YES, DO NOT take the tablets without

talking to your doctor again.

• Do you suffer from any blood vessel disorders which your doctor does not know about?
• Do you suffer from asthma or diabetes?
• Do you have or have you ever had a stomach or duodenal ulcer?
• Are you taking any medicines to treat high blood pressure?
• Are you taking any cough or cold remedies, particularly nose drops or sprays?
• Are you taking any other medicines which your doctor does not know about?
• Are you pregnant or trying to become pregnant?
• Are you breast-feeding?

If the answer to any of these questions is

YES, tell your doctor or pharmacist.

• It is important to take your tablets at the right times. You must take them as instructed by your doctor. The label will tell you how many to take and how often. If it does not, or you are not sure, ask your doctor or pharmacist.
• You should swallow the tablets with a drink of water.
• Do not stop taking your tablets suddenly. Ask your doctor first.
• If you forget to take a dose take it as soon as you remember. Then go on as before. DO NOT take a double dose.
• If you accidentally take too many Ismelin tablets tell your doctor immediately or contact your nearest casualty department.

These tablets sometimes cause unwanted

effects in some people. If you get any of

the following tell your doctor.

• Swelling of the ankles, feet or lower legs.
• Skin rash or itching for the first time.
• Persistent fever.

• Upset stomach.
• Drowsiness, dizziness or blurred vision.
• Headache or pins and needles.
• Stuffy nose.

These effects are often mild and may wear

off after a few days' treatment. If they are

severe or last for more than a few days, tell

your doctor. Also, if your tablets upset you

in any other way, tell your doctor.

• If you feel dizzy or drowsy when you start to take these tablets, do not drive or operate machinery until these effects have worn off.
• Be careful when drinking alcohol – it may affect you more than usual.
• Strenuous physical exercise, especially during hot weather, might make you feel dizzy.

• REMEMBER: this medicine is for YOU. Only a doctor can prescribe it for you. Never give it to someone else. It may harm them even if they have the same symptoms as you.